Sharon Barone Selected Research

trans-sodium crocetinate (crocetin)

4/2024	Carbonic Anhydrase 2 Deletion Delays the Growth of Kidney Cysts Whereas Foxi1 Deletion Completely Abrogates Cystogenesis in TSC.
1/2023	Identification of an Electrogenic 2Cl-/H+ Exchanger, ClC5, as a Chloride-Secreting Transporter Candidate in Kidney Cyst Epithelium in Tuberous Sclerosis.
9/2022	Renal Transcriptome and Metabolome in Mice with Principal Cell-Specific Ablation of the Tsc1 Gene: Derangements in Pathways Associated with Cell Metabolism, Growth and Acid Secretion.
1/2021	Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex.
1/2019	Tuberous sclerosis complex exhibits a new renal cystogenic mechanism.

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Sharon Barone Research Topics

Disease

9	Renal Insufficiency (Renal Failure) 04/2024 - 05/2003
7	Reperfusion Injury 01/2014 - 05/2003
5	Tuberous Sclerosis (Bourneville's Disease) 04/2024 - 01/2019
5	Hypertension (High Blood Pressure) 02/2023 - 02/2009
5	Acute Kidney Injury (Acute Renal Failure) 09/2019 - 05/2003
4	Neoplasms (Cancer) 04/2024 - 01/2017
4	Wounds and Injuries (Trauma) 03/2024 - 01/2014
4	Alkalosis 01/2018 - 08/2012
3	Cysts 04/2024 - 01/2021
3	Ischemia 01/2014 - 05/2003
2	Fibrosis (Cirrhosis) 03/2024 - 06/2006
2	Cystic Fibrosis (Mucoviscidosis) 01/2018 - 11/2013
2	Acidosis 08/2013 - 10/2009
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2023
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 01/2023
1	COVID-19 02/2022
1	Gliosis 10/2020
1	Neuroinflammatory Diseases 10/2020
1	Ataxia (Dyssynergia) 10/2020
1	Angiomyolipoma 01/2019
1	Deafness (Deaf Mutism) 10/2018
1	Goiter 10/2018
1	Congenital Hypothyroidism (Cretinism) 10/2018
1	Heart Block 01/2018
1	Familial Hypophosphatemia (Phosphate Diabetes) 01/2016
1	Hypercalciuria 01/2016
1	Polyuria 01/2013
1	Edema (Dropsy) 08/2012
1	Nephrotic Syndrome (Syndrome, Nephrotic) 08/2012
1	Hypokalemia 08/2012
1	Heart Failure 08/2012
1	Renal Tubular Acidosis (Distal Renal Tubular Acidosis) 10/2009
1	Hypotension (Low Blood Pressure) 02/2009
1	Weight Gain 02/2009
1	Adenoma (Adenomas) 12/2006
1	Diarrhea 12/2006
1	Peptic Ulcer (Peptic Ulcers) 08/2005

Drug/Important Bio-Agent (IBA)

7	PolyaminesIBA 03/2024 - 04/2009
6	SaltsIBA 02/2023 - 02/2009
5	trans-sodium crocetinate (crocetin)IBA 04/2024 - 01/2019
5	EnzymesIBA 03/2024 - 04/2009
4	RNA (Ribonucleic Acid)IBA 03/2024 - 05/2004
4	ChloridesIBA 01/2023 - 12/2006
3	Cisplatin (Platino)FDA LinkGeneric 03/2024 - 05/2003
3	AcidsIBA 01/2021 - 10/2009
3	Proteins (Proteins, Gene)FDA Link 10/2020 - 01/2003
3	SpermidineIBA 01/2014 - 04/2009
3	SpermineIBA 01/2014 - 04/2009
2	Carbonic Anhydrases (Carbonic Anhydrase)IBA 04/2024 - 01/2021
2	FructoseIBA 02/2023 - 02/2009
2	Proton-Translocating ATPases (ATPase, H+)IBA 01/2023 - 01/2021
2	Polyamine OxidaseIBA 09/2019 - 07/2010
2	Chloride-Bicarbonate AntiportersIBA 01/2018 - 01/2018
2	Adenosine Triphosphate (ATP)IBA 01/2018 - 05/2003
2	Bicarbonates (Hydrogen Carbonate)IBA 01/2018 - 08/2013
2	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 01/2017 - 01/2013
2	ThiazidesIBA 01/2017 - 01/2013
2	DiureticsIBA 01/2013 - 08/2012
2	StathminIBA 06/2006 - 05/2004
1	Mechanistic Target of Rapamycin Complex 1IBA 04/2024
1	Lipocalin-2IBA 03/2024
1	Fibronectins (Fibronectin)IBA 03/2024
1	CollagenIBA 03/2024
1	VimentinIBA 03/2024
1	SugarsIBA 02/2023
1	Sucrose (Saccharose)IBA 02/2023
1	Tuberous Sclerosis Complex 2 ProteinIBA 09/2022
1	Tuberous Sclerosis Complex 1 ProteinIBA 09/2022
1	VaccinesIBA 02/2022
1	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 01/2021
1	ElectrolytesIBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	SynucleinsIBA 10/2020
1	TransglutaminasesIBA 10/2020
1	IodidesIBA 10/2018
1	AnionsIBA 10/2018
1	Thyroid HormonesIBA 10/2018
1	Uricosuric AgentsIBA 01/2018
1	Probenecid (Benemid)FDA LinkGeneric 01/2018
1	HET0016IBA 01/2016
1	Indomethacin (Indometacin)FDA LinkGeneric 01/2016
1	20-hydroxy-5,8,11,14-eicosatetraenoic acidIBA 01/2016
1	Chloride Channels (Chloride Channel)IBA 11/2013
1	CalciumIBA 11/2013
1	ColforsinIBA 11/2013
1	Complementary DNA (cDNA)IBA 11/2013
1	Drinking WaterIBA 08/2013
1	SodiumIBA 01/2013
1	Member 3 Solute Carrier Family 12IBA 08/2012
1	diamine N-acetyltransferase (spermidine acetyltransferase)IBA 07/2010
1	EndotoxinsIBA 07/2010
1	AcetyltransferasesIBA 04/2009
1	Starch (Cornstarch)IBA 02/2009
1	Phenobarbital (Luminal)FDA Link 02/2009
1	Carrier Proteins (Binding Protein)IBA 06/2006
1	CreatinineIBA 06/2006
1	TubulinIBA 06/2006
1	Thrombospondin 1IBA 12/2005
1	DNA (Deoxyribonucleic Acid)IBA 12/2005

Therapy/Procedure

1	Therapeutics 02/2022